Calcium Gradient Hypothesis

Silicone -Calcium Gradient Hypothesis

• Intercellular Calcium drive the adhesion levels between cells and molecules
• The elastic and  load strength of the epidermis is regulated by the calcium gradient
• The dermal Calcium gradient determines scar remodeling through collagen -collegenase production
• Silicone  acts as a calcium -phosphorous sink drawing  calcium towards  the skin surface 
• Phosophorous -Calcium close the wound in an accelerated manner promoting scarless healing
• Developed by Tom Fallon of Rejuveness
• Mostly a European and dermotological Hypotheis 
• The calcium gradient  must replace Hydration as the working Hypothesis of Silicone and scarring